The 71-year-old wife of the president tested negative Monday but developed "cold-like symptoms late in the evening," her communications director Elizabeth Alexander said in a statement.

Jill Biden tested positive while on holiday in South Carolina.

US First Lady Jill Biden has tested positive for Covid-19 and developed mild symptoms, the White House said Tuesday, two weeks after her husband Joe Biden contracted the virus for a second time.

A subsequent rapid antigen test was negative, but a more detailed PCR test was positive, Alexander said.

The first lady has been prescribed a course of the oral antiviral pill Paxlovid and will isolate for at least five days.

She "is double-vaccinated, twice boosted, and only experiencing mild symptoms," Alexander added.

Jill Biden tested positive while on holiday in South Carolina, where she is staying at a private residence and will return to the White House after two consecutive negative tests, her aide said.